Naproxen-induced thrombocytopenia. Issue 4 (1st October 2020)

• Record Type: Journal Article
• Authors: Sahu, Nitasa; Roy, Justin; Vunnam, Rama; Golamari, Reshma; Jain, Rohit
• Is Part Of: Proceedings. Volume 33:Issue 4(2020)
• Page Start: 653
• Page End: 654
• Publication Date: 2020-10-01
• Subjects: Drug-induced thrombocytopenia -- hematology -- internal medicine; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2020.1798724
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract: Thrombocytopenia has many mechanisms with broad differentials. A detailed history and physical, with timely diagnostic testing, is necessary to parse out the underlying etiology. Clinicians should maintain a high suspicion for drug-induced thrombocytopenia when there is an acute drop in the platelet level after exposure to commonly implicated drugs. Drug-induced thrombocytopenia is not well defined, as reporting is voluntary and not critically reviewed. Oftentimes, the culprit is not the drug itself, but a drug metabolite, which is difficult to prove with drug-dependent antibody testing. Here we present a case where naproxen led to hemarthrosis secondary to drug-induced thrombocytopenia.