Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia. Issue 3 (20th November 2020)

• Record Type: Journal Article
• Authors: Tsvetanov, Kamen A.; Gazzina, Stefano; Jones, P. Simon; van Swieten, John; Borroni, Barbara; Sanchez‐Valle, Raquel; Moreno, Fermin; Laforce, Robert; Graff, Caroline; Synofzik, Matthis; Galimberti, Daniela; Masellis, Mario; Tartaglia, Maria Carmela; Finger, Elizabeth; Vandenberghe, Rik; de Mendonça, Alexandre; Tagliavini, Fabrizio; Santana, Isabel; Ducharme, Simon; Butler, Chris; Gerhard, Alexander; Danek, Adrian; Levin, Johannes; Otto, Markus; Frisoni, Giovanni; Ghidoni, Roberta; Sorbi, Sandro; Rohrer, Jonathan D.; Rowe, James B.
• Other Names: Afonso Sónia investigator.; Almeida Maria Rosario investigator.; Anderl‐Straub Sarah investigator.; Andersson Christin investigator.; Antonell Anna investigator.; Archetti Silvana investigator.; Arighi Andrea investigator.; Balasa Mircea investigator.; Barandiaran Myriam investigator.; Bargalló Nuria investigator.; Bartha Robart investigator.; Bender Benjamin investigator.; Benussi Luisa investigator.; Bessi Valentina investigator.; Binetti Giuliano investigator.; Black Sandra investigator.; Bocchetta Martina investigator.; Borrego‐Ecija Sergi investigator.; Bras Jose investigator.; Bruffaerts Rose investigator.; Caroppo Paola investigator.; Cash David investigator.; Castelo‐Branco Miguel investigator.; Convery Rhian investigator.; Cope Thomas investigator.; Cosseddu Maura investigator.; de Arriba María investigator.; Di Fede Giuseppe investigator.; Díaz Zigor investigator.; Moore Katrina M investigator.; Duro Diana investigator.; Fenoglio Chiara investigator.; Ferrari Camilla investigator.; Ferreira Carlos investigator.; Ferreira Catarina B. investigator.; Flanagan Toby investigator.; Fox Nick investigator.; Freedman Morris investigator.; Fumagalli Giorgio investigator.; Gabilondo Alazne investigator.; Gasparotti Roberto investigator.; Gauthier Serge investigator.; Gazzina Stefano investigator.; Giaccone Giorgio investigator.; Gorostidi Ana investigator.; Greaves Caroline investigator.; Guerreiro Rita investigator.; Heller Carolin investigator.; Hoegen Tobias investigator.; Indakoetxea Begoña investigator.; Jelic Vesna investigator.; Jiskoot Lize investigator.; Karnath Hans‐Otto investigator.; Institutet Karolinska investigator.; Keren Ron investigator.; Langheinrich Tobias investigator.; Leitão Maria João investigator.; Lladó Albert investigator.; Lombardi Gemma investigator.; Loosli Sandra investigator.; Maruta Carolina investigator.; Mead Simon investigator.; Meeter Lieke investigator.; Miltenberger Gabriel investigator.; van Minkelen Rick investigator.; Mitchell Sara investigator.; Nacmias Benedetta investigator.; Neason Mollie investigator.; Nicholas Jennifer investigator.; Olives Jaume investigator.; Padovani Alessandro investigator.; Panman Jessica investigator.; Papma Janne investigator.; Piaceri Irene investigator.; Pievani Michela investigator.; Pijnenburg Yolande investigator.; Polito Cristina investigator.; Premi Enrico investigator.; Prioni Sara investigator.; Prix Catharina investigator.; Rademakers Rosa investigator.; Redaelli Veronica investigator.; Rittman Tim investigator.; Rogaeva Ekaterina investigator.; Rosa‐Neto Pedro investigator.; Rossi Giacomina investigator.; Rossor Martin investigator.; Santiago Beatriz investigator.; Scarpini Elio investigator.; Schönecker Sonja investigator.; Semler Elisa investigator.; Shafei Rachelle investigator.; Shoesmith Christen investigator.; Tábuas‐Pereira Miguel investigator.; Tainta Mikel investigator.; Taipa Ricardo investigator.; Tang‐Wai David investigator.; Thomas David L investigator.; Thompson Paul investigator.; Thonberg Hakan investigator.; Timberlake Carolyn investigator.; Tiraboschi Pietro investigator.; Vandamme Philip investigator.; Vandenbulcke Mathieu investigator.; Veldsman Michele investigator.; Verdelho Ana investigator.; Villanua Jorge investigator.; Warren Jason investigator.; Wilke Carlo investigator.; Woollacott Ione investigator.; Wlasich Elisabeth investigator.; Zetterberg Henrik investigator.; Zulaica Miren investigator.;
• Is Part Of: Alzheimer's & dementia. Volume 17:Issue 3(2021)
• Page Start: 500
• Page End: 514
• Publication Date: 2020-11-20
• Subjects: frontotemporal dementia (FTD) -- functional magnetic resonance imaging (fMRI) -- network connectivity -- presymptomatic; Alzheimer's disease -- Periodicals; Alzheimer Disease -- Periodicals; Dementia -- Periodicals; Démence; Maladie d'Alzheimer; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.83
• DOI: 10.1002/alz.12209
• Languages: English
• ISSNs: 1552-5260

Abstract

Abstract: Introduction: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). Methods: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data‐driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. Results: There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviorally relevant structural and functional network differences. Structure‐function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non‐carriers, and increased with proximity to the expected onset of disease. Discussion: Our findings suggest that the maintenance of functional network connectivity enables carriers to maintain cognitive performance.