Baclofen-induced toxicity in renal disease with neurotoxicity and skin rash. Issue 3 (3rd July 2019)

• Record Type: Journal Article
• Authors: Pathak, Lakshmi Kant; Athavale, Ambarish; Martinez, Ian
• Is Part Of: Proceedings. Volume 32:Issue 3(2019)
• Page Start: 425
• Page End: 426
• Publication Date: 2019-07-03
• Subjects: Baclofen toxicity -- morbilliform rash -- neurotoxicity; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2019.1618659
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract: Baclofen is approved by the Food and Drug Administration for spasticity and is also used off-label for trigeminal neuralgia, cluster headache, and substance abuse dependency. Baclofen is 90% renally excreted and has a variable threshold for toxicity in patients with chronic kidney disease. We present a case of accidental overdose of baclofen in a 58-year-old woman with intractable trigeminal neuralgia. She presented with baclofen neurotoxicity symptoms including confusion and tremors and had a morbilliform rash in the dorsum of both hands. This simultaneous presentation is rare and has never been reported. Her symptoms resolved after hemodialysis treatment.