First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency. (4th July 2022)

• Record Type: Journal Article
• Authors: Ruan, X.; Du, J.; Lu, D.; Duan, W.; Jin, F.; Kong, W.; Wu, Y.; Dai, Y.; Yan, S.; Yin, C.; Li, Y.; Cheng, J.; Jia, C.; Liu, X.; Wu, Q.; Gu, M.; Ju, R.; Xu, X.; Yang, Y.; Jin, J.; Korell, M.; Montag, M.; Liebenthron, J.; Mueck, A. O.
• Is Part Of: Climacteric. Volume 25:Number 4(2022)
• Page Start: 421
• Page End: 424
• Publication Date: 2022-07-04
• Subjects: Ovarian tissue cryopreservation -- transplantation -- first -- live birth -- China -- premature ovarian insufficiency; Menopause -- Periodicals; Menopause -- Hormone therapy -- Periodicals; Menopause -- Periodicals; Estrogen Replacement Therapy -- Periodicals; Gynecology -- Periodicals; Societies, Medical -- Periodicals; 612.665
• DOI: 10.1080/13697137.2022.2064215
• Languages: English
• ISSNs: 1369-7137

Abstract

Abstract: Objective: This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency in China. Methods: A patient with myelodysplastic syndrome received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and six ovarian cortex strips were thawed and transplanted into her peritoneal pocket 2 years later. Results: Pregnancy occurred spontaneously 27 months after grafting, and a healthy girl was born at 38 weeks gestation. Until now, the child has developed normally without any major diseases. Conclusions: We report the first live birth resulting from ovarian tissue cryopreservation and transplantation in China.