Enhancement of antibiotic activity by phytocompounds of Turnera subulata. Issue 16 (17th August 2020)

• Record Type: Journal Article
• Authors: Freitas, Cicero L. A.; Santos, Francisca F. P.; Dantas-Junior, Orlando M.; Inácio, Vital V.; Matias, Edinardo F. F.; Quintans-Júnior, Lucindo J.; Aguiar, José J. S.; Coutinho, Henrique D. M.
• Is Part Of: Natural product research. Volume 34:Issue 16(2020)
• Page Start: 2384
• Page End: 2388
• Publication Date: 2020-08-17
• Subjects: Aminoglycosides -- Turnera subulata -- antibacterial -- bacterial resistance; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1537273
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The present study aimed to evaluate the antibacterial and modulatory activity of the Turnera subulate methyl extract in isolation or in combination with aminoglycoside antibiotics, using the microdilution method. The Turnera subulata methyl extract was used in isolation in the antibacterial assays and in combination with antibiotics in the modulation assays. All tests were performed in triplicates. The Turnera subulata methyl extract presented both antibacterial and antibiotic-modulatory effects in vitro, in isolation and in association with aminoglycosides. The extract activity depends on the bacterial strain and may be associated with the presence of tannins and flavonols. However, further studies are required to characterize the Turnera subulata potential for the development of new drugs against multiresistant bacteria. Graphical Abstract: