Cytotoxic triterpenoid saponins from the root of Anemone tomentosa (Maxim.) Pei. Issue 24 (16th December 2020)

• Record Type: Journal Article
• Authors: Zhang, Yu; Niu, Xueni; Jia, Yingchao; Lv, Chongning; Wang, Jing; Jia, Lingyun; Lu, Jincai
• Is Part Of: Natural product research. Volume 34:Issue 24(2020)
• Page Start: 3462
• Page End: 3469
• Publication Date: 2020-12-16
• Subjects: Anemone tomentosa (Maxim.) Pei -- triterpenoid saponins -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1578765
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new triterpenoid saponins, tomentoside T1 (1 ) and tomentoside T2 (2 ), together with eleven known compounds (3–13 ) were obtained from ethyl acetate extracts of Anemone tomentosa (Maxim.) Pei by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. The cytotoxic activity of all isolated saponins was evaluated on MDA-MB-231 and PC-3 cell lines. Compounds 5 and 7 showed significant cytotoxicity against with MDA-MB-231 cell and PC-3 cell with IC50 values of 3.73–4.21 μM and 3.53–5.37 μM, respectively. Graphical Abstract: