Promising treatment strategies to combat Staphylococcus aureus biofilm infections: an updated review. Issue 10 (4th December 2020)

• Record Type: Journal Article
• Authors: Seethalakshmi, P. S.; Rajeev, Riya; Kiran, George Seghal; Selvin, Joseph
• Is Part Of: Biofouling. Volume 36:Issue 10(2020)
• Page Start: 1159
• Page End: 1181
• Publication Date: 2020-12-04
• Subjects: Antimicrobial resistance -- anti-biofilm agents -- microbial bioactive metabolites -- nanoparticles -- repurposed drugs; Marine fouling organisms -- Periodicals; Materials -- Biodeterioration -- Periodicals; Fouling -- Periodicals; Biodegradation -- Periodicals; Environmental Microbiology -- Periodicals; Water Microbiology -- Periodicals; 576.165
• DOI: 10.1080/08927014.2020.1857743
• Languages: English
• ISSNs: 0892-7014

Abstract

Abstract: Staphylococcus aureus is a leading cause of nosocomial and community-acquired infections. The formation of biofilm by this pathogen renders it resilient to antimicrobial agents, which complicates the treatment of such infections. S. aureus can form biofilms with other pathogens and cause polymicrobial infections recalcitrant to antimicrobial agents. Therefore, anti-biofilm agents against which this bacterium cannot develop resistance are a highly desirable treatment strategy. Nanoparticles and some non-antimicrobial drugs proposed for various clinical purposes have proven to be excellent antibacterial and anti-biofilm agents to control S. aureus biofilm infections. A variety of chemically distinct compounds capable of acting as anti-biofilm agents against S. aureus have been extracted from microbial sources. This review explains the characteristics of S. aureus biofilms, emphasizing the therapeutic potential of nanoparticles, repurposed drugs, and anti-biofilm agents from microbial sources to combat S. aureus biofilm infections. Graphical Abstract: