Effects of electronic cigarette on platelet and vascular function after four months of use. (July 2020)

• Record Type: Journal Article
• Authors: Ikonomidis, Ignatios; Katogiannis, Konstantinos; Kostelli, Gavriella; Kourea, Kallirhoe; Kyriakou, Elias; Kypraiou, Athina; Tsoumani, Maria; Andreadou, Ioanna; Lambadiari, Vaia; Plotas, Panagiotis; Thymis, Ioannis; Tsantes, Argirios E.
• Is Part Of: Food and chemical toxicology. Volume 141(2020)
• Publication Date: 2020-07
• Subjects: Electronic cigarette -- Platelets -- Light transmission aggregometry -- PFA-100 -- Pulse wave velocity -- Oxidative stress; con-cig conventional cigarette -- e-cig electronic cigarette -- LTA Light Transmission Aggregometry -- PFA Platelet Function Analyzer -- MDA malondialdehyde -- PWV Pulse Wave Velocity -- PLTs Platelets -- HCT Hematocrit -- PPP Platelet Poor Plasma -- PRP Platelet Rich Plasma -- CO Carbon monoxide; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2020.111389
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: We examined the effects of electronic cigarette on platelet and vascular function after 4 months of use compared to tobacco smoking. Forty smokers without cardiovascular disease were randomized to smoke either conventional cigarettes or an electronic cigarette (nicotine concentration of 12 mg/ml). At baseline and after four months, we measured a) platelet function by Platelet Function Analyzer PFA-100 and Light Transmission Aggregometry, b) pulse wave velocity, c) plasma malondialdehyde levels as oxidative stress index and d) the exhaled CO level. After 4 months, continuation of conventional cigarette smoking further impaired platelet function compared to vaping as assessed by PFA (mean increase 27.1 vs 11.6 s, p for interaction = 0.048) and by LTA (decline 24.1 vs 9.4%, p for interaction = 0.045). Conversely, compared to smoking, vaping resulted in greater reduction of exhaled CO (6.9 ppm vs 2.6, p for interaction < 0.001), improvement of PWV (decrease of 0.8 m/s vs increase of 0.8 m/s, p for interaction = 0.020) and reduction of MDA (reduction 0.13 vs increase 0.19 nmol/L, p for interaction = 0.035). Switching to electronic cigarette for 4 months has a neutral effect on platelet function while it reduces arterial stiffness and oxidative stress compared to tobacco smoking. Highlights: Electronic Cigarette vaping for four months, has a neutral effect on platelet aggregation of healthy smokers. Continuation of tobacco cigarette smoking further deteriorates platelet function during 4 months of use. Electronic cigarette vaping improves arterial elastic properties and oxidative stress after 4 months of use Tobacco cigarette smoking causes further impairment of arterial elasticity and oxidative stress during 4 months of use