Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses. Issue 3 (30th August 2015)

• Record Type: Journal Article
• Authors: Darrow, Sabrina M.; Illmann, Cornelia; Gauvin, Caitlin; Osiecki, Lisa; Egan, Crystelle A.; Greenberg, Erica; Eckfield, Monika; Hirschtritt, Matthew E.; Pauls, David L.; Batterson, James R.; Berlin, Cheston M.; Malaty, Irene A.; Woods, Douglas W.; Scharf, Jeremiah M.; Mathews, Carol A.
• Is Part Of: Psychiatry research. Volume 228:Issue 3(2015)
• Page Start: 816
• Page End: 825
• Publication Date: 2015-08-30
• Subjects: Tourette Syndrome -- Obsessive–compulsive disorder -- Attention deficit/hyperactivity disorder -- Web-based assessment; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2015.05.017
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Collecting phenotypic data necessary for genetic analyses of neuropsychiatric disorders is time consuming and costly. Development of web-based phenotype assessments would greatly improve the efficiency and cost-effectiveness of genetic research. However, evaluating the reliability of this approach compared to standard, in-depth clinical interviews is essential. The current study replicates and extends a preliminary report on the utility of a web-based screen for Tourette Syndrome (TS) and common comorbid diagnoses (obsessive compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD)). A subset of individuals who completed a web-based phenotyping assessment for a TS genetic study was invited to participate in semi-structured diagnostic clinical interviews. The data from these interviews were used to determine participants׳ diagnostic status for TS, OCD, and ADHD using best estimate procedures, which then served as the gold standard to compare diagnoses assigned using web-based screen data. The results show high rates of agreement for TS. Kappas for OCD and ADHD diagnoses were also high and together demonstrate the utility of this self-report data in comparison previous diagnoses from clinicians and dimensional assessment methods. Highlights: We compared a web-based screen to standard, clinical interviews in a TS sample. Concordance between TS diagnoses given by the two methods was high. The web-based screen gave reliable OCD and ADHD diagnoses. Use of DSM criteria was more useful than quantitative scores to assess OCD and ADHD. Previous diagnosis by a clinician may also be a useful screening method.