Hyperuricosuria, hematuria, and novel bladder images with IgA nephropathy. Issue 2 (4th March 2021)

• Record Type: Journal Article
• Authors: Birkemeier, Krista L.; Hogg, Ronald J.; Patel, Darshan B.; Acosta, Alisa A.; Waxman, Jeffrey A.
• Is Part Of: Proceedings. Volume 34:Issue 2(2021)
• Page Start: 294
• Page End: 296
• Publication Date: 2021-03-04
• Subjects: Bladder ultrasound -- gross hematuria -- hyperuricosuria -- trigone; Medicine -- Periodicals; Medicine; Medicine -- Periodicals; Periodicals; Electronic journals; 616.005
• DOI: 10.1080/08998280.2020.1860428
• Languages: English
• ISSNs: 0899-8280

Abstract

Abstract: Episodic (recurrent) macroscopic hematuria in patients with IgA nephropathy is usually associated with a benign prognosis, although some patients experience a transient fall in glomerular filtration rate during the episodes. We present a 15-year-old girl with mild IgA nephropathy who had multiple episodes of macroscopic hematuria associated with severe but transient decreases in estimated glomerular filtration rate, low levels of serum uric acid, and marked increases in fractional excretion of uric acid. Ultrasound studies showed marked inflammatory changes in the bladder, especially involving the trigone. Cystoscopic findings were consistent with these changes. We hypothesize that the macroscopic hematuria may have resulted, at least in part, from hyperuricosuria causing acute irritation of the bladder mucosa in the trigone area.