Arylations with nitroarenes for one-pot syntheses of triaryl-methanols and tetraarylmethanes. Issue 14 (15th June 2022)

• Record Type: Journal Article
• Authors: Li, Jie; Zou, Dong; Wang, Bo; İşcan, Ayşegül; Jin, Huimin; Chen, Lingfeng; Zhou, Fan; Walsh, Patrick J.; Liang, Guang
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 14(2022)
• Page Start: 3854
• Page End: 3861
• Publication Date: 2022-06-15
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00576j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Triarylmethanols are well-known core structures in natural products and pharmacologically relevant compounds. Abstract : Triarylmethanols are well-known core structures in natural products and pharmacologically relevant compounds. In general, transition metal-based catalysts or highly reactive organometallics are employed for the synthesis of these compounds. Herein, we report the regioselective tandem C(sp 3 )–H arylation/oxidation of diarylmethanes with nitroarenes to generate arylated alcohols. The present method is general, mild, green, and conducted in air at room temperature. Furthermore, use of triarylmethanes as pro-nucleophiles provides straightforward access to select tetraarylmethanes through a cross-dehydrogenative coupling process.