Centiloid scale analysis for 18F-THK5351 PET imaging in Alzheimer's disease. (February 2021)

• Record Type: Journal Article
• Authors: Yamao, Tensho; Miwa, Kenta; Wagatsuma, Kei; Shigemoto, Yoko; Sato, Noriko; Akamatsu, Go; Ito, Hiroshi; Matsuda, Hiroshi
• Is Part Of: Physica medica. Volume 82(2021)
• Page Start: 249
• Page End: 254
• Publication Date: 2021-02
• Subjects: PET -- Tau -- Alzheimer's disease -- Centiloid scale -- Quantification; Medical physics -- Periodicals; Biophysics -- Periodicals; Biophysics -- Periodicals; Imagerie médicale -- Périodiques; Radiothérapie -- Périodiques; Rayons X -- Sécurité -- Mesures -- Périodiques; Physique -- Périodiques; Médecine -- Périodiques; 610.153
• DOI: 10.1016/j.ejmp.2021.02.017
• Languages: English
• ISSNs: 1120-1797

Abstract

Highlights: We applied the Centiloid method for 18 F-THK5351 PET images on AD. The whole cerebellum as SUVR reference showed low variance and high effect size between AD and cognitive normal. AD specific region of accumulation of 18 F-THK5351 was extracted using voxel-wise analysis. Target region was not included typical off-target regions of 18 F-THK5351. SUVR value of the cognitively unimpaired elderly was 1.227. Abstract: Purpose: A standardized method for quantification is required for analyzing PET data, but such standards have not been established for tau PET imaging. The Centiloid scale has recently been proposed as a standard method for quantifying amyloid deposition on PET imaging. Therefore, the present study aimed to apply the Centiloid scale to 18 F-THK5351 PET imaging in Alzheimer's disease (AD). Methods: We acquired 18 F-THK5351 PET, 11 C-PiB PET, and MR images from 47 cognitively normal (CN) individuals and 28 patients with AD with mild to moderate dementia. PET images were spatially normalized to Montreal Neurological Institute space. The PET signals were then normalized using the signal in the reference volume of interest (VOI). Target VOI for specific 18 F-THK5351 retention in AD was extracted by voxel-wise comparison of PET images between the 47 CN individuals and 16 AD patients with moderate dementia. Scale anchor points were defined by the CN individuals as 0-anchor points and by that of the average of the typical AD patients as 100-anchor points. Results: Specific retention of 18 F-THK5351 was predominant in the angular gyrus, inferior temporal cortex, and parieto-occipital regions in patients with AD. Standardized uptake value ratio (SUVR) of 1.227 and 1.797 were defined as 0- and 100-anchor points, respectively. 18 F-THK5351 PET data could be expressed using the Centiloid scale, with the SUVR of the 18 F-THK5351 PET images converted to Centiloid using our VOI, the standard Centiloid reference VOI, and the following equation: Centiloid = 169.0 × SUVR–204.6. Conclusion: Centiloid methods can be applied to tau PET imaging using 18 F-THK5351.