Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens. (July 2020)

• Record Type: Journal Article
• Authors: Meerpoel, Celine; Vidal, Arnau; Huybrechts, Bart; Tangni, Emmanuel K.; De Saeger, Sarah; Croubels, Siska; Devreese, Mathias
• Is Part Of: Food and chemical toxicology. Volume 141(2020)
• Publication Date: 2020-07
• Subjects: ANOVA analysis of variances -- AUC area under the curve -- BEN Balkan endemic nephropathy -- BW body weight -- CIT citrinin -- Cl total body clearance -- Cmax maximal plasma concentration -- F absolute oral bioavailability -- gof goodness-of-fit -- HO−CIT dihydrocitrinone -- IV intravenous administration -- kel elimination rate constant -- LC−MS/MS liquid chromatography tandem mass spectrometry -- NOAEL no observed adverse effect level -- OTA ochratoxin A -- PO per os -- T1/2el elimination half-life -- Tmax time to maximal plasma concentration -- Vd volume of distribution; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2020.111365
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: A comprehensive toxicokinetic analysis of citrinin (CIT) revealed interspecies differences for all toxicokinetic parameters and in absolute oral bioavailability. Oral bioavailability for CIT was complete for broilers (113–131%), while ranging from 37 to 44% in pigs. CIT was more rapidly absorbed in pigs (Tmax = 0.92 h) compared to broiler chickens (Tmax = 7.33 h). The elimination of CIT was slower in pigs (T1/2el = 26.81 h after intravenous (IV) administration) compared to chickens (T1/2el = 1.97 h after IV administration), due to the striking difference in clearance (Cliv= 9.87 mL/h/kg for pigs versus Cliv = 863.09 mL/h/kg for broilers). Also, the volume of distribution differed significantly between pigs (Vd = 0.30 L/kg after IV administration) and chickens (Vd = 2.46 L/kg after IV administration). However, plasma protein binding did not differ statistically significant (91–98%). It is imperative to further investigate biotransformation and elimination pathways in different species, including humans. Highlights: Toxicokinetic characteristics of citrinin showed species dependency. Citrinin was completely absorbed in broiler chickens, but incomplete in pigs. The elimination half-life for citrinin was lower for broilers compared to pigs. Similarities and differences in toxicokinetics of ochratoxin A were described.