Association between pelvic inflammatory disease and subsequent salpingectomy on the risk for ovarian cancer. (March 2021)

• Record Type: Journal Article
• Authors: Falconer, Henrik; Yin, Li; Salehi, Sahar; Altman, Daniel
• Is Part Of: European journal of cancer. Volume 145(2021)
• Page Start: 38
• Page End: 43
• Publication Date: 2021-03
• Subjects: Salpingectomy -- Ovarian cancer -- Pelvic inflammatory disease; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2020.11.046
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: Aim: Salpingectomy is associated with a lower risk for ovarian cancer, suggesting that the fallopian tubes constitute the origin of the disease. It is unclear whether the observed effect is mediated by pelvic inflammatory disease (PID); a major indication for salpingectomy and implicated in the aetiology of ovarian cancer. Methods: In this population-based cohort study, we used nationwide registry-based data on women exposed for PID with and without subsequent salpingectomy (n = 97, 912) compared with the unexposed population (n = 5, 429, 174) between 1973 and 2010. The effect of hormone treatment was considered in a subanalysis. Results: Of the exposed women, 9538 women underwent salpingectomy during the study period. There was a significant association between PID and ovarian cancer (hazard ratio [HR] 1.44, 95% confidence interval [CI] 1.31–1.59), whereas an inverse association was observed for exposed women with subsequent salpingectomy (HR 0.55, 95% CI 0.36–0.83). Salpingectomy performed on other indications (n = 24, 895) was associated with a lower incidence of ovarian cancer (HR 0.72, 95% CI 0.56–0.93). No effect modification was observed for the use of oral contraceptives or hormonal replacement therapy. Conclusion: Salpingectomy is associated with a lower incidence of ovarian cancer regardless of indication. Highlights: Pelvic inflammatory disease (PID) is associated with an increased incidence of ovarian cancer. Women with a history of PID with subsequent salpingectomy had a significantly lower risk for ovarian cancer. Salpingectomy performed on other indications than PID conferred a lower incidence for ovarian cancer. Salpingectomy should be considered as a risk-reducing measure for ovarian cancer.