Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo. (1st July 2022)

• Record Type: Journal Article
• Authors: Marques Meccatti, Vanessa; de Souza Moura, Larissa; Guerra Pinto, Juliana; Ferreira-Strixino, Juliana; Abu Hasna, Amjad; Alves Figueiredo-Godoi, Lívia Mara; Campos Junqueira, Juliana; Marcucci, Maria Cristina; Paula Ramos, Lucas de; Carvalho, Claudio Antonio Talge; Pucci, Cesar Rogério; de Oliveira, Luciane Dias
• Other Names: Issever Halim Academic Editor.
• Is Part Of: International journal of dentistry. Volume 2022(2022)
• Publication Date: 2022-07-01
• Subjects: Dentistry -- Periodicals; Dentistry; Dentistry -- Periodicals; Electronic journals; Periodicals; 617.6
• DOI: 10.1155/2022/5837864
• Languages: English
• ISSNs: 1687-8728

Abstract

Abstract : Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa) ; the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes "LED" on Candida albicans and Candida tropicalis in vitro ; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis . The extract of C. longa 100 mg/mL and curcumin 200 μ g/mL do not show toxicity on Galleria mellonella model.