The danger of dichloromethane in the synthesis and application of imidazole-based dyes. (August 2022)

• Record Type: Journal Article
• Authors: Liu, Zhizhou; Li, Chao; Chen, Chen; Wang, Tong; He, Liang; Nan, Xueyan; Li, Li; Qian, Qing; Bai, Pengli
• Is Part Of: Dyes and pigments. Volume 204(2022)
• Publication Date: 2022-08
• Subjects: Imidazole -- Ultraviolet oxidation of DCM -- Hydrogen peroxide detection; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2022.110404
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: In this paper, a lophine-based phenol compound has been prepared and identified as an efficient chromophore for the determination of hydrogen peroxide (H2 O2 ) with enzymatic method. A dry chemistry analytic agent was also prepared involving this compound, showing good accuracy in the determination of uric acid. However, a commonly used solvent dichloromethane (DCM) could react with this imidazole derivative when the reaction mixture was irradiated under UV (365 nm). We explored the possible mechanism and identified several by-products caused by the acidity and ultraviolet oxidation of DCM. Caution should be taken in the synthesis and application of such imidazole-based dyes in DCM, especially when phenol group was introduced to the imidazole moiety. Highlights: Lophine-based phenol compound showed high sensitivity in the detection of H2 O2 with enzymatic method. The potential danger of DCM in imidazole dyes synthesis an applications were explored. A highly sensitive dry chemistry analytic agent for uric acid determination was prepared.