Visible-light induced green synthesis of γ-deuterated carbonyl compounds. (6th July 2022)

• Record Type: Journal Article
• Authors: Hu, Lifu; Li, Ruining; Deng, Wei; Sun, Zhankui
• Is Part Of: Tetrahedron letters. Volume 101(2022)
• Publication Date: 2022-07-06
• Subjects: Deuteration -- Radical addition -- Green synthesis -- Visible-light; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153914
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Deuteration is a widely used labelling technique. Through a visible-light induced desulfurization and radical addition process in EtOAc-D2 O, we were able to develop the direct synthesis of γ-deuterated carbonyl compounds from α-sulfide ketones and alkenes. Products with different functionalities were efficiently synthesized with high-deuteration. This mild and metal-free method provides a valuable tool for medicinal and synthetic chemists.