Effect of the traditional Chinese herb Helminthostachys zeylanica on postsurgical recovery in patients with ankle fracture: A double-blinded randomized controlled clinical trial. (15th September 2022)

• Record Type: Journal Article
• Authors: Su, Chin-Horng; Chen, Ya-Chih; Yang, Ya-Hui; Wang, Chun-Yi; Ko, Po-Wei; Huang, Peng-Ju; Liaw, Chih-Chuang; Liao, Wen-Ling; Cheng, Tsung-Lin; Lee, Der-Yen; Lo, Lun-Chien; Hsieh, Ching-Liang
• Is Part Of: Journal of ethnopharmacology. Volume 295(2022)
• Publication Date: 2022-09-15
• Subjects: Helminthostachys zeylanica -- Ankle fracture -- Amino-terminal propeptide of type 1 procollagen (PINP) -- Bone healing; ALP serum alkaline phosphatase -- AOFAS American Orthopedic Foot and Ankle Society -- DBP diastolic blood pressure -- DM diabetes mellitus -- EIC electron ion collider -- ERK extracellular signal-regulated -- ESI electrospray ionization -- SGPT serum glutamic pyruvic transaminase -- HIV human immunodeficiency virus infection status -- HR heart rate -- HZ Helminthostachys zeylanica -- LC-MS liquid chromatography–mass spectrometry -- RHT radiographic healing time -- NMR nuclear magnetic response -- PINP serum amino-terminal propeptide of type 1 procollagen -- PPM parts per million -- SBP systolic blood pressure -- V1 first assessment -- V2 second assessment -- V3 third assessment -- UPLC ultraperformance liquid chromatography; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2022.115435
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: Helminthostachys zeylanica (HZ), which is also called "Dao-Di-U-Gon" in Taiwan, has anti-inflammatory and antiedema effects and is commonly used to treat edema in patients with fractures. The ugonin K component of HZ can induce osteogenesis and promote bone mineralization, its therapeutic effect, however, its therapeutic effect remains unclear. Therefore, the purpose of the present study was to investigate the effect of HZ on functional recovery in patients with ankle fractures requiring surgical treatment. Methods: A double-blinded, randomized, controlled study was conducted. A total of 45 patients with ankle fractures requiring surgical treatment were assigned to either the control group (n = 23 patients), which received the oral administration of HZ placebo 1.0 g t.i.d. for 42 days continuously, or to the treatment group (22 patients), which received HZ for 42 days. Results: The serum amino-terminal propeptide of type 1 procollagen (PINP) levels were similar in the first assessment (V1) between the control (45.90 ± 16.31 ng/mL) and treatment groups (52.61 ± 21.02 ng/mL; p = 0.240); the differences in PINP level between the third assessment (V3) and V1 were greater in the treatment group (35.84 ± 24.56 ng/mL) than in the control group (16.34 ± 11.97 ng/mL; p = 0.002). Radiographic healing time (RHT) was 9.09 ± 1.15 weeks in the treatment group, which was shorter than the 9.91 ± 0.79 weeks ( p = 0.012) in the control group. Conclusion: Oral administration of HZ for 42 days can increase serum PINP level and reduce the RHT. Therefore, HZ can be used to treat patients with ankle fractures requiring surgical treatment. However, a larger sample size is needed in future studies. Graphical abstract: Image 1