Neutrophil metabolism in the cancer context. (October 2021)

• Record Type: Journal Article
• Authors: Bodac, Anita; Meylan, Etienne
• Is Part Of: Seminars in immunology. Volume 57(2021)
• Publication Date: 2021-10
• Subjects: Acetyl-CoA acetyl-coenzyme-A -- ARG arginine -- CMP common myeloid progenitor -- DNI delta neutrophil index -- ER endoplasmic reticulum -- FAO fatty acid β-oxidation -- FATP fatty acid transport protein -- G6P glucose-6-phosphate -- G6PC3 glucose-6-phosphatase-β -- G-CSF granulocyte colony-stimulating factor -- GM-CSF granulocyte-macrophage colony-stimulating factor -- GLUT glucose transporter -- GLR glucose-to-lymphocyte ratio -- GMP granulocyte-monocyte progenitor -- HDN high-density neutrophil -- HIF-1α hypoxia-inducible factor 1-alpha -- HSC hematopoietic stem cell -- iNOS inducible nitric oxide synthase -- LDL low-density lipoprotein -- LDN low-density neutrophil -- LOX lectin-type oxidized LDL receptor -- MDSC myeloid-derived suppressor cell -- MMP matrix metalloproteinase -- NADH nicotinamide adenine dinucleotide -- NADPH nicotinamide adenine dinucleotide phosphate -- NE neutrophil elastase -- NET neutrophil extracellular trap -- NO nitric oxide -- NOX NADPH oxidase -- NSCLC non-small cell lung cancer -- OSM oncostatin M -- OXPHOS oxidative phosphorylation -- PET positron emission tomography -- PMN polymorphonuclear leukocyte -- PPP pentose phosphate pathway -- ROS reactive oxygen species -- TAN tumor-associated neutrophil -- TCA tricarboxylicacid -- TME tumor-microenvironment; Neutrophil metabolism -- Tumor-associated neutrophils -- Cancer metabolism; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2021.101583
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: Neutrophils are critical innate immune cells for the host anti-bacterial defense. Throughout their lifecycle, neutrophils are exposed to different microenvironments and modulate their metabolism to survive and sustain their functions. Although tumor cell metabolism has been intensively investigated, how neutrophil metabolism is affected in cancer remains largely to be discovered. Neutrophils are described as mainly glycolytic cells. However, distinct tumor-associated neutrophil (TAN) states may co-exist in tumors and adapt their metabolism to exert different or even opposing activities ranging from tumor cell killing to tumor support. In this review, we gather evidence about the metabolic mechanisms that underly TANs' pro- or anti-tumoral functions in cancer. We first discuss how tumor-secreted factors and the heterogenous tumor microenvironment can have a strong impact on TAN metabolism. We then describe alternative metabolic pathways used by TANs to exert their functions in cancer, from basic glycolysis to more recently-recognized but less understood metabolic shifts toward mitochondrial oxidative metabolism, lipid and amino acid metabolism and even autophagy. Last, we discuss promising strategies targeting neutrophil metabolism to combat cancer.