Repurposing antidepressants for anticancer drug discovery. Issue 7 (July 2022)

• Record Type: Journal Article
• Authors: Song, Yihui; Yang, Xiaoke; Yu, Bin
• Is Part Of: Drug discovery today. Volume 27:Issue 7(2022)
• Page Start: 1924
• Page End: 1935
• Publication Date: 2022-07
• Subjects: AML acute myeloid leukemia -- CRC colorectal cancer -- FAO flavin-dependent amine oxidase -- GSCs glioma stem cells -- HCC hepatocellular carcinoma -- HDAC1/2 histone deacetylates 1/2 -- HNSCC head and neck squamous cell carcinoma -- hSCCs human squamous cell carcinoma cells -- LSD1 lysine specific demethylase 1 -- LSD2 lysine-specific demethylase 2 -- MAO-A monoamine oxidase A -- MAO-B monoamine oxidase B -- MAOIs monoamine oxidase inhibitors -- MDS myelodysplastic syndrome -- NF-κB nuclear factor κ-light-chain-enhancer of activated B -- non-APL nonacute promyelocytic leukemia -- NSCLC non-small cell lung cancer -- SARIs serotonin antagonist and reuptake inhibitors -- SHMT serine hydroxymethyltransferase -- SNRIs serotonin-norepinephrine reuptake inhibitors -- SSAO semicarbazide-sensitive amine oxidases -- SSRIs selective serotonin reuptake inhibitors -- TCAs tricyclic antidepressants -- TCP tranylcypromine -- TeCAs tetracyclic antidepressants; Drug repurposing -- Antidepressants -- Anticancer drug discovery; Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2021.10.019
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: Antidepressants can be potentially repurposed for anticancer drug discovery. Antidepressants exhibit the antitumor activity with different mechanisms. Repurposing tranylcypromine has led to the discovery of LSD1 inhibitors for cancer therapy. Repurposing antidepressants may provide hopes for patients suffering from depression and cancers simultaneously. Abstract : Drug repurposing is an attractive strategy for identifying new indications for existing drugs. Three approved antidepressants have advanced into clinical trials for cancer therapy. In particular, further medicinal chemistry efforts with tranylcypromine (TCP) have led to the discovery of several TCP-based histone lysine specific demethylase 1 (LSD1) inhibitors that display therapeutic promise for treating cancer in the clinic. Thus repurposing antidepressants could be a promising strategy for cancer treatment. In this review, we illustrate the anticancer mechanisms of action of antidepressants and also discuss the challenges and future directions of repurposing antidepressants for anticancer drug discovery, to provide an overview of approved antidepressant cancer therapies.