Boric Acid‐Fueled ATP Synthesis by FoF1 ATP Synthase Reconstituted in a Supramolecular Architecture. (25th February 2021)

• Record Type: Journal Article
• Authors: Xu, Xia; Fei, Jinbo; Xu, Youqian; Li, Guangle; Dong, Weiguang; Xue, Huimin; Li, Junbai
• Is Part Of: Angewandte Chemie. Volume 133:Number 14(2021)
• Page Start: 7695
• Page End: 7698
• Publication Date: 2021-02-25
• Subjects: biochemical fuel -- biomimetic architectures -- biosynthesis -- proton gradients -- supramolecular assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202016253
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Significant strides toward producing biochemical fuels have been achieved by mimicking natural oxidative and photosynthetic phosphorylation. Here, different from these strategies, we explore boric acid as a fuel for tuneable synthesis of energy‐storing molecules in a cell‐like supramolecular architecture. Specifically, a proton locked in boric acid is released in a modulated fashion by the choice of polyols. As a consequence, controlled proton gradients across the lipid membrane are established to drive ATP synthase embedded in the biomimetic architecture, which facilitates tuneable ATP production. This strategy paves a unique route to achieve highly efficient bioenergy conversion, holding broad applications in synthesis and devices that require biochemical fuels. Abstract : Boric acid is explored as a fuel for tuneable ATP synthesis in a biomimetic supramolecular architecture. A proton is released from boric acid by a polyol, establishing a cross‐membrane proton gradient to achieve highly efficient ATP production. The assembled system integrates artificial and natural processes, holding promise in applications that require ATP.