Bowman's topography for improved detection of early ectasia. Issue 10 (27th June 2019)
- Record Type:
- Journal Article
- Title:
- Bowman's topography for improved detection of early ectasia. Issue 10 (27th June 2019)
- Main Title:
- Bowman's topography for improved detection of early ectasia
- Authors:
- Chandapura, Rachana
Salomão, Marcella Q.
Ambrósio, Renato
Swarup, Rishi
Shetty, Rohit
Sinha Roy, Abhijit - Abstract:
- Abstract: The aim of this study was to evaluate whether OCT topography of the Bowman's layer and artificial intelligence (AI) can result in better diagnosis of forme fruste (FFKC) and clinical keratoconus (KC). Normal (n = 221), FFKC (n = 72) and KC (n = 116) corneas were included. Some of the FFKC and KC patients had the fellow eye (VAE‐NT) with normal topography (n = 30). The Scheimpflug and OCT scans of the cornea were analyzed. The curvature and surface aberrations (ray tracing) of the anterior corneal surface [air‐epithelium (A‐E) interface in OCT] and epithelium‐Bowman's layer (E‐B) interface (in OCT only) were calculated. Four random forest models were constructed: (1) Scheimpflug only; (2) OCT A‐E only; (3) OCT E‐B only; (4) OCT A‐E and E‐B combined. For normal eyes, both Scheimpflug and OCT (A‐E and E‐B combined) performed equally in identifying these eyes ( P = .23). However, OCT A‐E and E‐B showed that most VAE‐NT eyes were topographically similar to normal eyes and did not warrant a separate classification based on topography alone. For identifying FFKC eyes, OCT A‐E and E‐B combined performed significantly better than Scheimpflug ( P = .006). For KC eyes, both Scheimpflug and OCT performed equally ( P = 1.0). Thus, OCT Topography of Bowman's layer significantly improved the detection of FFKC eyes. Abstract : The topography of the Bowman's layer is an exciting development in the field of corneal tomography. In this paper, we describe the application of Bowman'sAbstract: The aim of this study was to evaluate whether OCT topography of the Bowman's layer and artificial intelligence (AI) can result in better diagnosis of forme fruste (FFKC) and clinical keratoconus (KC). Normal (n = 221), FFKC (n = 72) and KC (n = 116) corneas were included. Some of the FFKC and KC patients had the fellow eye (VAE‐NT) with normal topography (n = 30). The Scheimpflug and OCT scans of the cornea were analyzed. The curvature and surface aberrations (ray tracing) of the anterior corneal surface [air‐epithelium (A‐E) interface in OCT] and epithelium‐Bowman's layer (E‐B) interface (in OCT only) were calculated. Four random forest models were constructed: (1) Scheimpflug only; (2) OCT A‐E only; (3) OCT E‐B only; (4) OCT A‐E and E‐B combined. For normal eyes, both Scheimpflug and OCT (A‐E and E‐B combined) performed equally in identifying these eyes ( P = .23). However, OCT A‐E and E‐B showed that most VAE‐NT eyes were topographically similar to normal eyes and did not warrant a separate classification based on topography alone. For identifying FFKC eyes, OCT A‐E and E‐B combined performed significantly better than Scheimpflug ( P = .006). For KC eyes, both Scheimpflug and OCT performed equally ( P = 1.0). Thus, OCT Topography of Bowman's layer significantly improved the detection of FFKC eyes. Abstract : The topography of the Bowman's layer is an exciting development in the field of corneal tomography. In this paper, we describe the application of Bowman's topography for improved detection of early ectasia such as forme fruste keratoconus. There was a significant improvement in its detection compared to conventional tomography. This technology based on OCT can potentially replace conventional tomography in anterior segment clinics. … (more)
- Is Part Of:
- Journal of biophotonics. Volume 12:Issue 10(2019)
- Journal:
- Journal of biophotonics
- Issue:
- Volume 12:Issue 10(2019)
- Issue Display:
- Volume 12, Issue 10 (2019)
- Year:
- 2019
- Volume:
- 12
- Issue:
- 10
- Issue Sort Value:
- 2019-0012-0010-0000
- Page Start:
- n/a
- Page End:
- n/a
- Publication Date:
- 2019-06-27
- Subjects:
- aberrations -- Bowman's layer -- ectasia -- keratoconus -- OCT -- topography
Photonics -- Periodicals
Optical materials -- Periodicals
Optics -- Periodicals
Medical instruments and apparatus -- Periodicals
621.3605 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1864-0648 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/jbio.201900126 ↗
- Languages:
- English
- ISSNs:
- 1864-063X
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 22319.xml