Cover Image. Issue 5 (3rd March 2021) - Griffa, Alessandra
Abstract : COVER ILLUSTRATION Idiopathic Normal Pressure Hydrocephalus (iNPH), the leading cause of reversible dementia in ageing, is currently underdiagnosed and poorly understood. Using functional brain imaging and molecular data, Griffa et al. demonstrate an alteration of Default Mode Network resting‐state dynamics in iNPH patients compared to healthy controls. These functional changes explain iNPH symptoms, are not driven by Alzheimer's disease pathology and are reverted by a CSF tap test through lumbar puncture. These findings demonstrate short‐term brain plasticity mechanisms after an invasive treatment and have possible implications for iNPH differential diagnosis and care management.