Intraoperative Assessment and Photothermal Ablation of the Tumor Margins Using Gold Nanoparticles. Issue 5 (18th January 2021)

• Record Type: Journal Article
• Authors: Wei, Qiaolin; Arami, Hamed; Santos, Hélder A.; Zhang, Hongbo; Li, Yangyang; He, Jian; Zhong, Danni; Ling, Daishun; Zhou, Min
• Is Part Of: Advanced science. Volume 8:Issue 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-01-18
• Subjects: gold nanoparticles -- intraoperative assessment -- photothermal ablation -- surface‐enhanced Raman scattering imaging -- tumor margins; Science -- Periodicals; 505
• DOI: 10.1002/advs.202002788
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Surgical resection is commonly used for therapeutic management of different solid tumors and is regarded as a primary standard of care procedure, but precise localization of tumor margins is a major intraoperative challenge. Herein, a generalized method by optimizing gold nanoparticles for intraoperative detection and photothermal ablation of tumor margins is introduced. These nanoparticles are detectable by highly sensitive surface‐enhanced Raman scattering imaging. This non‐invasive technique assists in delineating the two surgically challenged tumors in live mice with orthotopic colon or ovarian tumors. Any remaining residual tumors are also ablated by using post‐surgical adjuvant photothermaltherapy (aPTT), which results in microscale heat generation due to interaction of these nanoparticles with near‐infrared laser. Ablation of these post‐operative residual micro‐tumors prolongs the survival of mice significantly and delays tumor recurrence by 15 days. To validate clinical translatability of this method, the pharmacokinetics, biodistribution, Raman contrast, aPTT efficiency, and toxicity of these nanoparticles are also investigated. The nanoparticles have long blood circulation time (≈24 h), high tumor accumulation (4.87 ± 1.73%ID g −1 ) and no toxicity. This high‐resolution and sensitive intraoperative approach is versatile and can be potentially used for targeted ablation of residual tumor after resection within different organs. Abstract : The surface‐enhanced Raman scattering nanoparticles provide intraoperative detection and image‐guided cancer surgery. The remaining residual tumors are then ablated by a post‐surgical adjuvant photothermal therapy. Ablation of these residual microtumors, prolongs the survival significantly and reduces tumor recurrence. This high‐resolution and sensitive intraoperative approach is versatile and can be potentially used for targeted ablation of post‐resection residual tumors.