99mTC-sestamibi breast imaging: Current status, new ideas and future perspectives. (September 2022)

• Record Type: Journal Article
• Authors: Urbano, Nicoletta; Scimeca, Manuel; Tancredi, Virginia; Bonanno, Elena; Schillaci, Orazio
• Is Part Of: Seminars in cancer biology. Volume 84(2022)
• Page Start: 302
• Page End: 309
• Publication Date: 2022-09
• Subjects: 99mTC-sestamibi -- Dedicated breast gamma camera -- Breast cancer -- Bone metastasis -- Molecular imaging; Cancer -- Periodicals; Neoplasms -- Periodicals; Review Literature; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.semcancer.2020.01.007
• Languages: English
• ISSNs: 1044-579X

Abstract

Abstract: Here we proposed the most recent innovations in the use of Breast Specific Gamma Imaging with 99 mTc-sestamibi for the management of breast cancer patients. To this end, we reported the recent discoveries concerning: a) the implementation of both instrumental devices and software, b) the biological mechanisms involved in the 99 mTc-sestamibi uptake in breast cancer cells, c) the evaluation of Breast Specific Gamma Imaging with 99 mTc-sestamibi as predictive markers of metastatic diseases. In this last case, we also reported preliminary data about the capability of Breast Specific Gamma Imaging with 99 mTc-sestamibi to identify breast cancer lesions with high propensity to form bone metastatic lesions due to the presence of Breast Osteoblast-Like Cells.