QUANTIFICATION OF RETINAL CAPILLARY NONPERFUSION IN DIABETICS USING WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY. Issue 3 (March 2020)

• Record Type: Journal Article
• Authors: Alibhai, A. Yasin; De Pretto, Lucas R.; Moult, Eric M.; Or, Chris; Arya, Malvika; McGowan, Mitchell; Carrasco-Zevallos, Oscar; Lee, ByungKun; Chen, Siyu; Baumal, Caroline R.; Witkin, Andre J.; Reichel, Elias; de Freitas, Anderson Zanardi; Duker, Jay S.; Fujimoto, James G.; Waheed, Nadia K.
• Is Part Of: Retina. Volume 40:Issue 3(2020)
• Publication Date: 2020-03
• Subjects: diabetic retinopathy -- wide-field OCTA -- OCTA -- capillary nonperfusion -- retinal ischemia; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002403
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To combine advances in high-speed, wide-field optical coherence tomography angiography (OCTA) with image processing methods for semiautomatic quantitative analysis of capillary nonperfusion in patients with diabetic retinopathy (DR). Methods: Sixty-eight diabetic patients (73 eyes), either without retinopathy or with different degrees of retinopathy, were prospectively recruited for volumetric swept-source OCTA imaging using 12 mm × 12 mm fields centered at the fovea. A custom, semiautomatic software algorithm was used to quantify areas of capillary nonperfusion. Results: The mean percentage of nonperfused area was 0.1% (95% confidence interval: 0.0–0.4) in the eyes without DR; 2.1% (95% confidence interval: 1.2–3.7) in the nonproliferative DR eyes (mild, moderate, and severe), and 8.5% (95% confidence interval: 5.0–14.3) in the proliferative DR eyes. The percentage of nonperfused area increased in a statistically significant manner from eyes without DR, to eyes with nonproliferative DR, to eyes with proliferative DR. Conclusion: Capillary nonperfusion area in the posterior retina increases with increasing DR severity as measured by swept-source OCTA. Quantitative analysis of retinal nonperfusion on wide-field OCTA may be useful for early detection and monitoring of disease in patients with diabetes and DR. Abstract : Quantitative analysis of wide-field optical coherence tomography angiography images may be useful for early detection and monitoring of diabetic retinopathy progression in diabetics.