Variation in functional connectivity along anterior-to-posterior intraparietal sulcus, and relationship with age across late childhood and adolescence. (June 2015)

• Record Type: Journal Article
• Authors: Vinette, Sarah A.; Bray, Signe
• Is Part Of: Developmental cognitive neuroscience. Volume 13(2015)
• Page Start: 32
• Page End: 42
• Publication Date: 2015-06
• Subjects: IPS intraparietal sulcus -- hFEF putative human frontal eye fields -- hSMA human supplementary motor area -- DLPFC dorsolateral prefrontal cortex -- MT middle temporal -- fMRI functional magnetic resonance imaging -- TD typically developing -- ABIDE Autism Brain Imaging Data Exchange -- IRB institutional review board -- FWHM full width at half maximum -- WM white matter -- CSF cerebrospinal fluid -- FWE family wise error -- DAN dorsal attention network -- FPN fronto-parietal network -- DMN default mode network -- ROI region-of-interest -- TPJ temporoparietal junction -- ASD autism spectrum disorders -- TR repetition time -- TE echo time -- FOV field of view -- MNI Montreal Neurological Institute -- VLPFC ventrolateral prefrontal cortex -- SM sensorimotor -- FG fusiform gyrus -- Calc peri-calcarine cortex -- OT occipto-temporal -- MO mid occipital -- PT posterior thalamus -- VMPFC ventromedial prefrontal cortex -- IPL inferior parietal lobule -- PCUN precuneus -- Mid Temp middle temporal -- CN caudate nucleus -- WASI Wechsler Abbreviated Scale of Intelligence -- DAS Differential Ability Scales -- PPVT Peabody Picture Vocabulary Test -- FIQ Full Scale IQ -- VIQ Verbal IQ -- PIQ Performance IQ -- BA Brodmann area -- BOLD blood oxygenation level-dependent; Functional connectivity -- Resting-state fMRI -- IPS -- Visual-spatial -- Attention -- Visuotopic; Cognitive neuroscience -- Periodicals; Developmental neurobiology -- Periodicals; Neuropsychology -- Periodicals; Neuropsychiatry -- Periodicals; 612.8233
• DOI: 10.1016/j.dcn.2015.04.004
• Languages: English
• ISSNs: 1878-9293

Abstract

Highlights: Assessed age-effects (6–20 years) on intraparietal sulcus (IPS) functional connectivity. IPS seeds spanned anterior-to-posterior axis of the IPS (IPS0-4). Positive functional connectivity age-effects observed for IPS3-4 and visual regions. Negative age-effects: IPS-superior parietal and IPS-medial orbitofrontal cortices. Age-effects on IPS functional connectivity relatively modest and non-linear. ABSTRACT: The intraparietal sulcus (IPS), a region in the dorsal attention network (DAN), has been implicated in multi-sensory attention and working memory. Working memory and attention develop across childhood; changes in functional connectivity within the DAN may relate to this maturation. Previous findings regarding fronto-parietal intrinsic functional connectivity age-effects were mixed. Our study aimed to circumvent limitations of previous work using a large cross-sectional sample, 183 typically developing participants 6.5–20 years, from the Autism Brain Imaging Data Exchange, and seed regions along the anterior-to-posterior axis of the IPS. These seeds, IPS0-4, were entered into functional connectivity models. Group-level models investigated differential connectivity along the IPS and relationships with age. Anterior IPS3/4 exhibited greater connectivity with sensorimotor/pre-motor regions. Posterior IPS0/1 demonstrated greater connectivity with dorsal and ventral visual regions. Positive age-effects were found between IPS3-4 and visual regions. Negative age-effects were found between IPS and superior parietal and medial orbitofrontal cortices. Follow-up region of interest analyses were used to estimate age-effects for DAN and anticorrelated default mode network regions. Results suggest age-effects on IPS functional connectivity are relatively modest, and may differ pre- and across-adolescence. Studying typical age-related connectivity variability within this network may help to understand neurodevelopmental disorders marked by impaired attention.