264  Cognitive and imaging correlates in cerebral amyloid angiopathy subthypes. Issue 6 (27th May 2022)

• Record Type: Journal Article
• Authors: Bonifacio, Guendalina; Chan, Edgar; Islam, Afm; Werring, David
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 93:Issue 6(2022)
• Page Start: A89
• Page End: A89
• Publication Date: 2022-05-27
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2022-ABN.291
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Common clinical subtypes of CAA are CAA with intracerebral haemorrhage (CAA-ICH), with cognitive decline (CAA-cog), and with Transient Focal Neurological Episodes (CAA-TFNE); most studies of cognition and neuroimaging to date have focussed on CAA-ICH. We therefore evaluated the cognitive and imaging phenotypes across all the CAA subgroups. This is a retrospective cross-sectional study of cognition and imaging in 99 patients; 70 (71%) with CAA and 29 (29%) with presumed hypertensive arteriopathy (non-CAA). We measured impairment across the cognitive domains using a standardised test battery, and we described the imaging biomarkers via visual rating of standardised MRI scans. Most patients had impairment in more than 2 domains (69%). We found impairment in the executive domain in 71% of patients, followed by non-verbal IQ (59%) and verbal IQ (48%). Patients with CAA-TFNE had similar impairments across cognitive domains to CAA-ICH. CAA-cog performed worse than CAA-ICH with verbal recognition memory (p<0.05). With regards to imaging findings, the groups differed significantly for several small vessel disease markers (e.g. moderate to severe cSS in CAA-TFNE compared to CAA-ICH and CAA-cog, >2 lobar CMBs in CAA-ICH and CAA-cog compared to CAA-TFNE). Our findings confirm high rates of cognitive impairment across CAA subtypes, including CAA-TFNE. The cognitive profile of CAA-TFNE was similar to that of CAA-ICH, despite differences in neuroimaging findings. Hence, the effects of CAA on cognition can occur regardless of the presence of ICH. [e-mail]