The gateway reflex: breaking through the blood barriers. (10th September 2021)

• Record Type: Journal Article
• Authors: Murakami, Kaoru; Tanaka, Yuki; Murakami, Masaaki
• Is Part Of: International immunology. Volume 33:Number 12(2021)
• Page Start: 743
• Page End: 748
• Publication Date: 2021-09-10
• Subjects: autoreactive CD4+ T cells -- IL-6 amplifier -- neuroimmune interaction -- neuromodulation -- tissue-specific autoimmune diseases; Immunology -- Periodicals; 616.079
• DOI: 10.1093/intimm/dxab064
• Languages: English
• ISSNs: 0953-8178

Abstract

Abstract: We have been studying inflammatory diseases, with a special focus on IL-6, and discovered two concepts related to inflammation development. One is the gateway reflex, which is induced by the activation of specific neural circuits followed by establishing gateways for autoreactive CD4 + T cells to pass through blood barriers toward the central nervous system (CNS) and retina during tissue-specific inflammatory diseases. We found that the formation of these gateways is dependent on the IL-6 amplifier, which is machinery for enhanced NF-κB activation in endothelial cells at specific sites. We have found five gateway reflexes in total. Here, we introduce the gateway reflex and the IL-6 amplifier.