Where all the Roads Meet? A Crossover Perspective on Host Factors Regulating SARS-CoV-2 infection. Issue 5 (15th March 2022)

• Record Type: Journal Article
• Authors: Lata, Sneh; Mishra, Ritu; Arya, Ravi P.; Arora, Pooja; Lahon, Anismrita; Banerjea, Akhil C.; Sood, Vikas
• Is Part Of: Journal of molecular biology. Volume 434:Issue 5(2022)
• Publication Date: 2022-03-15
• Subjects: COVID-19 -- SARS-CoV-2 -- CRISPR -- host factors -- viral diseases; COVID-19 coronavirus disease 19 -- RRA robust-rank aggregation -- ACE2 angiotensin-converting enzyme 2 -- TMPRSS2 transmembrane protease serine 2 -- RSV Respiratory Syncytial Virus -- CSNK2B casein kinase 2 subunit beta -- VACV vaccinia virus -- HPV Human Papilloma Virus -- HIV-1 Human Immunodeficiency Virus 1 -- HSV-1 Herpes Simplex Virus-1 -- GDI2 GDP dissociation inhibitor beta -- IAV Influenza A virus -- TMV Tobacco Mosaic Virus -- VSV Vesicular Somatitis Virus -- CHIKV Chikungunya Virus -- SLC35B2 solute carrier family 35 member B2 -- DENV Dengue Virus -- SBV Schmallenberg virus -- DDX DEAD-box RNA helicase -- VPS vacuolar protein sorting -- HCV Hepatitis C virus -- TBSV Tomato bushy stunt virus -- CIRV Carnation Italian ringspot virus -- ARPP-19 cyclic adenosine monophosphate-regulated phosphoprotein 19 -- PP2A protein phosphatase 2A -- HCC hepatocellular carcinoma -- C1QTNF7 C1q and tumor necrosis factor-related protein 7 -- CTRP C1q complement/TNF-related protein -- SNPs single nucleotide polymorphisms -- ALG Alpha-1, 3-glucosyltransferase -- CDGS carbohydrate-deficient glycoprotein syndrome -- CDG1C congenital disorder of N-linked glycosylation type 1C -- LIMA-1 LIM domain and actin binding-1 -- EPLIN epithelial protein lost in neoplasm -- SREBP3 sterol regulatory element binding protein 3 -- COG conserved oligomeric Golgi -- BCOR BCL6 interacting co-repressor -- HDACS histone deacetylases -- EBV Epstein–Barr virus -- LRRN2 leucine-rich repeat neuronal protein 2 -- TLR toll-like receptors; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2021.167403
• Languages: English
• ISSNs: 0022-2836

Abstract

Graphical abstract: Highlights: Fifteen common human host proteins are involved in SARS-CoV-2 infection. Each common host factor interacts with one or more SARS-CoV-2 viral proteins. Most of the identified host factors interact with other known human viruses. Abstract: COVID-19 caused by SARS-CoV-2 is the latest pandemic which has thrown the world into an unprecedented social and economic uncertainties along with huge loss to humanity. Identification of the host factors regulating the replication of SARS-CoV-2 in human host may help in the development of novel anti-viral therapies to combat the viral infection and spread. Recently, some research groups used genome-wide CRISPR/Cas screening to identify the host factors critical for the SARS-CoV-2 replication and infection. A comparative analysis of these significant host factors (p < 0.05) identified fifteen proteins common in these studies. Apart from ACE2 (receptor for SARS-CoV-2 attachment), other common host factors were CSNK2B, GDI2, SLC35B2, DDX51, VPS26A, ARPP-19, C1QTNF7, ALG6, LIMA1, COG3, COG8, BCOR, LRRN2 and TLR9. Additionally, viral interactome of these host factors revealed that many of them were associated with several SARS-CoV-2 proteins as well. Interestingly, some of these host factors have already been shown to be critical for the pathogenesis of other viruses suggesting their crucial role in virus-host interactions. Here, we review the functions of these host factors and their role in other diseases with special emphasis on viral diseases.