A turn-on fluorescent probe for palladium(II) detection with a large Stokes shift and lysosomes-targeting ability. (20th July 2022)

• Record Type: Journal Article
• Authors: Wang, Donghui; Hou, Haoran; Chen, Wenlong; Wu, Yingnan; Peng, Xiaojun; Song, Fengling
• Is Part Of: Tetrahedron letters. Volume 102(2022)
• Publication Date: 2022-07-20
• Subjects: Fluorescent probe -- Stokes shift -- Lysosomes -- Tsuji-Trost reaction -- Palladium ion; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153932
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: Although a number of palladium(II) probes have been developed, most of them have small Stokes shifts and lack good subcellular targeting ability. In this paper, a reaction-based probe (DCF-MPYM-Pd) has been designed and synthesized for palladium(II) detection. The probe was constructed by a fluorescein derivative as the fluorophore and an allyl ester group as the recognition group. The probe exhibited fast response time (5 min), high sensitivity and specificity. Importantly, it has a large Stokes shift and lysosomal targeting capability. In addition, it was demonstrated that the probe can be used to sense palladium(II) in living cells and can accumulate specifically in lysosomes.