An efficient one-pot, three-component route to novel push–pull 1, 3-benzodithiol-2-ylidenes via copper-catalyzed bis-CS bond formation. (20th July 2022)

• Record Type: Journal Article
• Authors: Kumar, Yogendra; Antony Palluruthiyil, Mary; Iniyavan, Pethaperumal; Ila, Hiriyakkanavar
• Is Part Of: Tetrahedron letters. Volume 102(2022)
• Publication Date: 2022-07-20
• Subjects: Push-pull 1, 3-benzodithiol-2-ylidenes -- Copper-catalyzed CS bond formation -- Dithioate salt -- Active methylene compounds -- Dihalo-coupling partner; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153951
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: An efficient one-pot, three-component synthesis of novel push–pull 1, 3-benzodithiol-2-ylidenes, involving reaction of active methylene compounds with CS2 in the presence of NaH as the base, followed by in situ Cu-catalyzed bis-CS coupling of the resulting dithioate salts with 1-bromo-2-iodobenzenes has been reported. The methodology involves readily available starting materials and tolerates a broad range of functional groups.