Minimal EEG channel selection for depression detection with connectivity features during sleep. (August 2022)

• Record Type: Journal Article
• Authors: Zhang, Yangting; Wang, Kejie; Wei, Yu; Guo, Xinwen; Wen, Jinfeng; Luo, Yuxi
• Is Part Of: Computers in biology and medicine. Volume 147(2022)
• Publication Date: 2022-08
• Subjects: Depression detection -- Sleep EEG -- Network connectivity -- EEG channel Selection -- Temporal region; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2022.105690
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Background and objectives: Sleeping cortical electroencephalogram (EEG) has the potential for depression detection, for different sleep structure and cortical connection have been proved in depressed patients. However, the operation of multi-channel sleep EEG recording is cumbersome and requires laboratory equipment and professional sleep technician. Here, we focus on the depression detection using minimal sleep EEG channels. Methods: Sixteen channels of EEG data of 30 patients with depression and 30 age-matched normal controls were recorded during sleep. Power spectral density of each single EEG channel was calculated, followed by measuring the symbolic transfer entropy (STE) and weighed phase lag index (WPLI) between EEG channel pairs in various frequency bands. Thereafter, these features were evaluated by F-score in the two-way classification (depression vs. control) of 30-s sleep EEG segments. Based on the F-score, entropy method was introduced to calculate the weight which could further assess the classification ability of various EEG channels or channel pairs. Finally, machine learning was implemented to verify the important EEG channels or channel pairs in depression diagnosis. Results: The features characterizing the inter-hemispheric connectivity in the posterior lobe, especially in the temporal lobe, showed high classification capacity. The classification accuracy of using two and four EEG channels in the temporal lobe were 97.96% and 99.61%, respectively. Conclusions: This study showed the possibility of using only a few sleep EEG channels for depression screening, which may greatly facilitate the diagnosis of depression outside the hospital. Highlights: This study proved the good performance of sleep EEG in depression detection. Inter-hemispheric connectivities in temporal region were important features. A few Inter-hemispheric EEG pairs can achieve a high depression detection accuracy. Depression detection can be realized with short-term sleep EEG signals.