Base-promoted cascade radical difluoroalkylation/cyclization of acrylamides for the synthesis of CF2-containing oxindoles and isoquinoline-1, 3-diones. (20th July 2022)

• Record Type: Journal Article
• Authors: Ma, Shidi; Zhou, Pengsheng; Fan, Xu; Li, Dianjun; Yang, Jinhui
• Is Part Of: Tetrahedron letters. Volume 102(2022)
• Publication Date: 2022-07-20
• Subjects: Base-promoted -- Difluoroalkylation -- Acrylamides -- Oxindoles -- Isoquinoline-1, 3-diones; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153933
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A base-promoted cascade radical difluoroalkylation/cyclization of acrylamides with ICF2 COOEt to synthesize CF2 -containing oxindoles and isoquinoline-1, 3-diones in moderate to excellent yields was developed under transition metal-free and catalyst-free conditions. This reaction tolerated a variety of functional groups and provided an alternative and mild method for the preparation of difluoroester-substituted five- and six-membered nitrogen-containing heterocyclic products.