Transtion-metal-free access to 2-arylphenethylamines through aryldiazonium ion catalyzed ring-opening of aziridines with arenes. (20th July 2022)

• Record Type: Journal Article
• Authors: Feng, Yunqiu; Huai, Menglin; Huang, Tian; Gao, Minghui; Tao, Chuanzhou
• Is Part Of: Tetrahedron letters. Volume 102(2022)
• Publication Date: 2022-07-20
• Subjects: Aryldiazonium ion -- Aziridine -- 2-Arylphenethylamine -- Transition-metal-free; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153920
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Aryldiazonium ions as catalysts to cleave aziridines. Access to a variety of 2-arylphenethylamines without transition metals. The cleavage of aziridines with arenes is highly regioselective. Gram-scale synthesis. Abstract: Aryldiazonium ions have been proven to catalyze effective cleavage of aziridines for the installation of varied aryl groups, providing access to a variety of 2-arylphenethylamines. This highly regioselective process, which can be performed at gram-scale, enjoys operational simplicity, as well as mild and metal-free conditions.