The antimalarial activity of 1, 2, 4‐trioxolane/trioxane hybrids and dimers: A review. Issue 7 (6th April 2022)

• Record Type: Journal Article
• Authors: Fang, Junman; Song, Feng; Wang, Fawei
• Is Part Of: Archiv der Pharmazie. Volume 355:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-06
• Subjects: 1, 2, 4‐trioxane -- 1, 2, 4‐trioxolane -- antimalarial -- artemisinin -- dimers -- drug resistance -- hybrid molecules -- Plasmodium falciparum -- structure–activity relationship; Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.202200077
• Languages: English
• ISSNs: 0365-6233

Abstract

Abstract: Malaria, a mosquito‐borne parasitic infection caused by protozoan parasites belonging to the genus Plasmodium, is a dangerous disease that contributes to millions of hospital visits and hundreds and thousands of deaths across the world, especially in Sub‐Saharan Africa. Antimalarial agents are vital for treating malaria and controlling transmission, and 1, 2, 4‐trioxolane/trioxane‐containing agents, especially artemisinin and its derivatives, own antimalarial efficacy and low toxicity with unique mechanisms of action. Moreover, artemisinin‐based combination therapies were recommended by the World Health Organization as the first‐line treatment for uncomplicated malaria infection and have remained as the mainstay of the treatment of malaria, demonstrating that 1, 2, 4‐trioxolane/trioxane derivatives are useful prototypes for the control and eradication of malaria. However, malaria parasites have already developed resistance to almost all of the currently available antimalarial agents, creating an urgent need for the search of novel pharmaceutical interventions for malaria. The purpose of this review article is to provide an emphasis on the current scenario (January 2012 to January 2022) of 1, 2, 4‐trioxolane/trioxane hybrids and dimers with potential antimalarial activity and the structure–activity relationships are also discussed to facilitate further rational design of more effective candidates. Abstract : The purpose of the present review article is to provide a comprehensive landscape of 1, 2, 4‐trioxolane/trioxane hybrids and dimers as antimalarial agents and the structure–activity relationships are also discussed to facilitate the further rational design of more effective candidates, covering articles published from January 2012 to January 2022.