Exosome-mediated remodeling of the tumor microenvironment: From local to distant intercellular communication. (1st September 2022)

• Record Type: Journal Article
• Authors: Huang, Yujuan; Kanada, Masamitsu; Ye, Jiaxiang; Deng, Yayan; He, Qian; Lei, Zhengyang; Chen, Yong; Li, Yongqiang; Qin, Peiwu; Zhang, Jinyan; Wei, Jiazhang
• Is Part Of: Cancer letters. Volume 543(2022)
• Publication Date: 2022-09-01
• Subjects: Extracellular vesicles -- Tumor cell-derived exosomes -- Invasion and metastasis -- Tumor microenvironment -- Clinical translation; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2022.215796
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Extracellular vesicles (EVs) are membrane-enveloped nanoscale particles that carry various bioactive signaling molecules secreted by cells. Their biological roles depend on the original cell type from which they are derived and their inclusions. Exosomes, a class of EVs, are released by almost all eukaryotic cell types, including tumor cells. Tumor cell-derived exosomes mediate signal transduction between tumor cells and surrounding non-tumor cells. This intercellular communication actively contributes to the remodeling of the tumor microenvironment (TME) to enable tumor growth, invasion, and metastasis. This review summarizes the latest progress in the exploration of exosome-mediated cell-cell communication implicated in TME remodeling and underlying mechanisms. We focus on the role of cell-cell interactions mediated by tumor cell-derived exosomes in promoting invasion and metastasis, and their potential as a therapeutic intervention target against distant metastasis. We also discuss the clinical translational significance of tumor-derived exosomes for early diagnosis, efficacy and progression evaluations. Highlights: Tumor-derived exosomes mediate intercellular signaling within the TME. Tumor-derived exosomes modulate the biological properties of various surrounding "non-tumor" cells. Exosome-mediated cell-cell communication contributes to the TME evolution that enables invasion and metastasis.