Three new jatrophane diterpenoids from Euphorbia peplus Linn. with activity towards autophagic flux. (August 2022)

• Record Type: Journal Article
• Authors: Pu, Xue-Xue; Ran, Xiao-Qian; Yan, Ying; Lu, Qing-Yun; Li, Jin-Cun; Li, Ying-Yao; Guan, Shi-Peng; Cao, Ming-Ming; Liu, Jie; Hao, Xiao-Jiang; Luo, Rong-Can; Di, Ying-Tong
• Is Part Of: Phytochemistry letters. Volume 50(2022)
• Page Start: 141
• Page End: 146
• Publication Date: 2022-08
• Subjects: Euphorbiaceae -- Euphorbia peplus -- Jatrophane diterpenoid -- Autophagic flux; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.06.007
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Three undescribed jatrophane diterpenoids, named euphpepluones P-R (1–3 ), were isolated from the whole plant Euphorbia peplus . The structures of these compounds were elucidated by spectroscopic methods. The absolute configuration of 1 was further assigned by X-ray crystallographic analysis. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 2 and 6 exhibited significant inhibition of autophagic flux. Graphical Abstract: ga1 Highlights: Three new jatrophane diterpenoids were isolated from Euphorbia peplus Linn. Their structures were determined by comprehensive spectroscopic analyses, including X-ray crystallographic analysis. Compounds 2 and 6 exhibited significant inhibition of autophagic flux.