Twenty years of investigation with the case of prosopagnosia PS to understand human face identity recognition.Part II: Neural basis. (13th August 2022)

• Record Type: Journal Article
• Authors: Rossion, Bruno
• Is Part Of: Neuropsychologia. Number 173(2022)
• Publication Date: 2022-08-13
• Subjects: Face identity recognition -- Prosopagnosia -- Single case -- PS -- Fusiform gyrus -- FFA -- OFA -- Right hemisphere -- Non-hierarchy; FIR Face Identity Recognition -- FFA Fusiform Face Area -- OFA Occipital Face Area -- IOG Inferior Occipital Gyrus -- STS Superior Temporal Sulcus -- LatMidFG Lateral MidFusiform gyrus -- EVC Early visual cortex -- fMRI Functional Magnetic Resonance Imaging -- EEG Electroencephalography -- DCM Dynamic Causal modeling -- TMS Transcranial Magnetic Stimulation -- VOTC Ventral Occipito-Temproal Cortex -- VATL Ventral Anterior Temporal Lobe; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2022.108279
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract : Patient PS sustained her dramatic brain injury thirty years ago, in 1992, the same year as the first report of a neuroimaging study of human face recognition.The present paper complements the review on the functional nature of PS's prosopagnosia (part I), illustrating how her case study directly, i.e., through neuroimaging investigations of her brain structure and activity, but also indirectly, through neural studies performed on other clinical cases and neurotypical individuals, inspired and constrained neural models of human face recognition.In the dominant right hemisphere for face recognition in humans, PS's main lesion concerns (inputs to) the inferior occipital gyrus (IOG), in a region where face-selective activity is typically found in normal individuals ('Occipital Face Area', OFA).Her case study initially supported the criticality of this region for face identity recognition (FIR) and provided the impetus for transcranial magnetic stimulation (TMS), intracerebral electrical stimulation, and cortical surgery studies that have generally supported this view.Despite PS's right IOG lesion, typical face-selectivity is found anteriorly in the middle portion of the fusiform gyrus, a hominoid structure.This face-selective right 'Fusiform Face Area' (FFA) has been widely considered as the most important region for human face recognition.This finding led to the original proposal of direct anatomico-functional connections from early visual cortices to the FFA, bypassing the IOG/OFA, a hypothesis supported by further neuroimaging studies of PS, other neurological cases and neuro-typical individuals with original visual stimulation paradigms, data recordings and analyses.The proposal of a lack of sensitivity to face identity in PS's right FFA due to defective reentrant inputs from the IOG/FFA has also been supported by other cases, functional connectivity and cortical surgery studies.Overall, neural studies of, and based on, the case of prosopagnosia PS strongly question the hierarchical organization of the human neural face recognition system, supporting a more flexible and dynamic view of this key social brain function in our species.