In-hospital mortality in SARS-CoV-2 stratified by sex diffrences: A retrospective cross-sectional cohort study. (July 2022)

• Record Type: Journal Article
• Authors: Al-Jarallah, Mohammed; Rajan, Rajesh; Dashti, Raja; Al Saber, Ahmad; Brady, Peter A.; Abdelnaby, Hassan; Alroomi, Moudhi; Aboelhassan, Wael; Abdullah, Mohammed; AlNasrallah, Noor; Al-Bader, Bader; Malhas, Haya; Ramadhan, Maryam; Alotaibi, Naser; Al Saleh, Mohammad; Almutairi, Farah; Zhanna, Kobalava D.
• Is Part Of: Annals of medicine and surgery. Volume 79(2022)
• Publication Date: 2022-07
• Subjects: Gender -- COVID-19 -- In-hospital mortality -- Sex -- SARS-CoV-2; Surgery -- Periodicals; Medicine -- Periodicals; General Surgery -- Periodicals; Education, Medical -- Periodicals; Periodicals; 617
• DOI: 10.1016/j.amsu.2022.104026
• Languages: English
• ISSNs: 2049-0801

Abstract

Abstract: Background: The aim of this study was to determine in-hospital mortality in patients presenting with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and to evaluate for any differences in outcome according to sex differences. Methods: Patients with SRS-CoV-2 infection were recruited into this retrospective cohort study between February 26 and September 8, 2020 and strаtified ассоrding tо the sex differences. Results: In tоtаl оf 3360 раtients (meаn аge 44 ± 17 years) were included, of whom 2221 (66%) were mаle. The average length of hospitalization was 13 days (range: 2–31 days). During hospitalization and follow-up 176 patients (5.24%) died. In-hospital mortality rates were significantly different according to gender (p=<0.001). Specifically, male gender was associated with significantly greater mortality when compared to female gender with results significant at an alpha of 0.05, LL = 28.67, df = 1, p = 0.001, suggesting that gender could reliably determine mortality rates. The coefficient for the males was significant, B = 1.02, SE = 0.21, HR = 2.78, p < 0.001, indicating that an observation in the male category will have a hazard 2.78 times greater than that in the female category. Multivariate logistic regression confirmed male patients admitted with SARS-CoV-2had higher сumulаtive аll-саuse in-hоsрitаl mоrtаlity (6.8% vs. 2.3%; аdjusted оdds rаtiо (аОR), 2.80; 95% (СI): [1.61–5.03]; р < 0.001). Conclusions: Male gender was an independent predictor of in-hospital mortality in this study. The mortality rate among male SARS-CoV-2 patients was 2.8 times higher when compared with females. Highlights: Male gender is an independent predictor of in-hospital mortality in COVID-19 patients. The mortality rate among male SARS-CoV-2 patients was 2.8 times higher when compared with females. Averаge length оf ICU stаy wаs longer in males.