Aerosol‐assisted open‐air plasma deposition of acrylate‐based composite coatings: Molecule release control through precursor selection. Issue 7 (22nd March 2022)

• Record Type: Journal Article
• Authors: Morand, Gabriel; Chevallier, Pascale; Tatoulian, Michael; Mantovani, Diego
• Other Names: Griesser Hans J. guestEditor.; Vasilev Krasimir guestEditor.
• Is Part Of: Plasma processes and polymers. Volume 19:Issue 7(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-22
• Subjects: aerosol‐assisted plasma deposition -- biodegradable coating -- controlled release -- entrapment in coating -- open‐air plasma; Plasma polymerization -- Periodicals; Plasma-enhanced chemical vapor deposition -- Periodicals; Plasma chemistry -- Periodicals
• DOI: 10.1002/ppap.202100252
• Languages: English
• ISSNs: 1612-8850

Abstract

Abstract: Aerosol‐assisted open‐air plasma allows the direct deposition of composite coatings with embedded bioactive agents. However, the deposition of biodegradable coatings for controlled drug release application remains challenging. In this study, an innovative precursor injection strategy is used to entrap tracers in coatings deposited from various acrylate‐based precursors: Acrylic acid (AA), methacrylic anhydride (MA), and 1, 4‐butanediol diacrylate (BDDA). Water immersion tests show dramatically different release kinetics ranging from over minutes to weeks and months for AA, MA, and BDDA, respectively. These different behaviors are correlated to the crosslinking degree and the hydrolysis rates of the crosslinking functions. This original approach allows controlled release of tracers entrapped in biodegradable acrylate‐based coatings and provides new insights for drug‐release application. Abstract : By using an innovative precursors injection strategy, open‐air aerosol‐assisted plasma allows the deposition of biodegradable coatings containing preserved and homogeneously entrapped water‐soluble agents. Depending on the used liquid acrylate‐based precursors, releases from minutes to weeks are obtained in water. Kinetic differences are associated with the crosslinking degree and functions stability to hydrolysis of the polymer. This process looks promising for the efficient production of biodegradable drug‐eluting coating.