Ionic melting salt imidazole hydrochloride mediated the decarboxylation of (hetero)aromatic carboxylic acids. (20th July 2022)

• Record Type: Journal Article
• Authors: Wang, Yin; Xu, Ping; Li, Yanwu; Wu, Yue; Liao, Siwei; Huang, Xin; Zhang, Xiuyu; Yuan, Jianyong
• Is Part Of: Tetrahedron letters. Volume 102(2022)
• Publication Date: 2022-07-20
• Subjects: Imidazole hydrochloride -- (hetero)Aromatic carboxylic acids -- Decarboxylation -- Amine; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2022.153941
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: This work focuses on an environmentally additive, imidazole hydrochloride, to mediate the decarboxylation of (hetero)aromatic carboxylic acids. Circumvention of metal additives, oxidants and other additives. Including advantages such as solvent-free, short reaction time, high yield and simple post-processing. Additives can be appropriately recovered for secondary utilization. Abstract: Imidazole hydrochloride, a hydrochloric acid carrier, was used to mediate the decarboxylation of ortho-para position amino-substituted aromatic acids and nitrogen-containing heterocyclic acids, which gave excellent yields within a short time. In addition, the method can be well adapted to a gram scale, and the imidazole hydrochloride additives can be appropriately recovered for secondary utilization.