Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4, 5)P2 split up. (July 2022)

• Record Type: Journal Article
• Authors: van Goor, Mark K.C.; van der Wijst, Jenny; Hoenderop, Joost G.J.
• Is Part Of: Cell calcium. Volume 105(2022)
• Publication Date: 2022-07
• Subjects: TRPV5 -- Calcium transport -- Calcium homeostasis -- PIP2 -- PI(4, 5)P2 -- Renal calcium, transport -- Cryo-EM -- Acidification; TRPV5 Transient Receptor Potential Vanilloid type 5 -- PI(4, 5)P2 phosphatidylinositol 4, 5-bisphosphate -- S1-6 Transmembrane helices 1-6 -- PKA Protein kinase A; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2022.102609
• Languages: English
• ISSNs: 0143-4160

Abstract

Highlights: Acidification causes PI(4, 5)P2 dissociation from TRPV5 and inhibits calcium reabsorption. Protein kinase A structurally competes with the calmodulin binding site on TRPV5 to prevent calcium-dependent channel inhibition. Abstract: TRPV5 is a highly selective calcium channel that finetunes urinary calcium excretion by reabsorbing calcium from the pro-urine. New structural findings show how PTH and pH control TRPV5 activity by altering the binding of endogenous ligands calmodulin and phosphatidylinositol 4, 5-bisphosphate (PI(4, 5)P2 ). Graphical abstract: Image, graphical abstract