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Cover Feature: Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous‐Flow Reactor and Consideration of a Mechanism for Reduced Over‐reaction through the Addition of Imidazole (Chem. Eur. J. 37/2022). Issue 37 (13th June 2022)
Record Type:
Journal Article
Title:
Cover Feature: Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous‐Flow Reactor and Consideration of a Mechanism for Reduced Over‐reaction through the Addition of Imidazole (Chem. Eur. J. 37/2022). Issue 37 (13th June 2022)
Main Title:
Cover Feature: Sequential Nucleophilic Substitution of Phosphorus Trichloride with Alcohols in a Continuous‐Flow Reactor and Consideration of a Mechanism for Reduced Over‐reaction through the Addition of Imidazole (Chem. Eur. J. 37/2022)
Abstract : Sequential nucleophilic substitution of phosphorus trichloride with alcohols has been achieved. Over‐reaction was suppressed by rapid mixing through micro‐flow technology, and asymmetric phosphotriesters containing acid‐ and/or base‐labile functional groups were synthesized in good to high yields. Moreover, a mechanistic study by using DFT calculations suggested interesting reaction pathways. More information can be found in the Research Article by S. Fuse and co‐workers (DOI: 10.1002/chem.202200932 ).