Mussel‐Inspired Ligand Clicking and Ion Coordination on 2D Black Phosphorus for Cancer Multimodal Imaging and Therapy. Issue 26 (26th May 2022)

• Record Type: Journal Article
• Authors: Li, Zimu; Yu, Yongkang; Zeng, Wenfeng; Ding, Fan; Zhang, Dan; Cheng, Wei; Wang, Miao; Chen, Hongzhong; Pan, Guoqing; Mei, Lin; Zeng, Xiaowei; Gao, Nansha
• Is Part Of: Small. Volume 18:Issue 26(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-26
• Subjects: biomimetic peptides -- black phosphorus -- cancer nanotechnology -- drug delivery -- synergistic therapy; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202201803
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: As a promising 2D nanocarrier, the biggest challenge of bare black phosphorus nanosheets (BP NSs) lies in the inherent instability, while it can be improved by surface modification strategies to a great extent. Considering the existing infirm BP NSs surface modification strategies, A mussels‐inspired strong adhesive biomimetic peptide with azide groups for surface modification to increase the stability of BP NSs is synthesized. The azide groups on the peptide can quickly and precisely bind to the targeting ligand through click chemistry, solving the problem of nonspecificity of secondary modification of other mussel‐mimicking materials. Besides, a catechol‐Gd 3+ coordination network is further constructed for magnetic resonance imaging (MRI) and inducing intracellular endo/lysosome escape. The fabricated BP‐DOX@Gd/(DOPA)4 ‐PEG‐TL nanoplatform exhibits enhanced antitumor abilities through synergetic chemo/photothermal effects both in vitro and in vivo. Abstract : A mussels‐inspired strong adhesive biomimetic peptide with azide groups for surface modification to increase the stability of black phosphorus nanosheets (BP NSs) is developed. With the quick and precise clicking binding and coordination, targeting ligand (TL) and Gd 3+ are introduced for tumor targeting, MRI and endo/lysosome escape. The fabricated BP‐DOX@Gd/(DOPA)4 ‐PEG‐TL nanoplatform exhibits enhanced antitumor abilities through synergetic chemo/photothermal effects both in vitro and in vivo.