Effect of dietary n-6: n-3 Poly-Unsaturated fatty acids ratio on gestational diabetes mellitus: a prospective cohort. (3rd July 2022)

• Record Type: Journal Article
• Authors: Fu, Yueqi; Yang, Ya; Zhu, Liyuan; Chen, Jing; Yu, Ningning; Zhao, Mei
• Is Part Of: Gynecological endocrinology. Volume 38:Number 7(2022)
• Page Start: 583
• Page End: 587
• Publication Date: 2022-07-03
• Subjects: Gestational diabetes mellitus -- maternal diet -- pregnancy -- n-3 fatty acids -- poly-unsaturated fatty acids; 妊娠糖尿病 -- 产妇饮食 -- 怀孕 -- n-3 脂肪酸 -- 多不饱和脂肪酸; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2022.2073995
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Objective: The aim of this study was to investigate the relationship between dietary n-6: n-3 poly-unsaturated fatty acids (PUFA) ratio and the risk of developing gestational diabetes mellitus (GDM). Materials and methods: A total of 100 pregnant women were prospectively included for detailed information on dietary intake at 16-18 weeks evaluated using a three-day food record, and subsequent GDM diagnosis at 24-28 weeks. Participants were divided into two groups for analysis: GDM group ( n = 22) and control group ( n = 78) based on oral glucose tolerance test results performed between 24 and 28 weeks. Results: The average dietary n-6: n-3 PUFA ratio in the control group was 5.63 ± 2.12 and that in the GDM group was 8.35 ± 3.45, within a significant difference ( p < .05). A significant difference was associated with a higher dietary n-6: n-3 PUFA ratio and GDM (adjusted odds ratio = 4.29, 95%confidence interval:1.303, 14.124). Conclusions: Higher dietary n-6: n-3 PUFA ratio was associated with higher odds of GDM. Given the small sample, further studies are required to confirm this hypothesis.