Improvement in sleep and itch and enhanced quality of life in adult patients with moderate-to-severe atopic dermatitis: results from a phase 3 trial of baricitinib therapy. (19th May 2022)

• Record Type: Journal Article
• Authors: Lio, Peter A.; Simpson, Eric L.; Han, George; Soung, Jennifer; Ball, Susan; Sun, Luna; Casillas, Marta; DeLozier, Amy M.; Ding, Yuxin; Eichenfield, Lawrence F.
• Is Part Of: Journal of dermatological treatment. Volume 33:Number 4(2022)
• Page Start: 2057
• Page End: 2062
• Publication Date: 2022-05-19
• Subjects: Atopic dermatitis -- baricitinib -- productivity -- quality of life; Skin -- Diseases -- Treatment -- Periodicals; Skin Diseases -- drug therapy -- Periodicals; Skin Diseases -- therapy -- Periodicals; 616.5
• DOI: 10.1080/09546634.2021.1914308
• Languages: English
• ISSNs: 0954-6634

Abstract

Abstract: Background: Baricitinib previously demonstrated improvements in itch and sleep disturbance versus placebo in adults with moderate-to-severe atopic dermatitis (AD). Objectives: Examine if itch and sleep improvements are associated with better quality of life (QoL) and productivity in patients with AD. Methods: Data were drawn from BREEZE-AD5 (NCT03435081). Itch and sleep improvement at Week 16 were defined using ≥4-point improvements in the Itch Numeric Rating Scale and ≥1.5 decreases in the number of nighttime awakenings since baseline, respectively. Patients with and without improvements were compared on Dermatology Life Quality Index (DLQI) and Work Productivity and Activity Impairment-AD scores. Changes from baseline were analyzed using ANCOVA with last observation carried forward. Proportions were analyzed using logistic regression with non-responder imputation. Results: Greater proportions of patients with versus without itch improvement indicated no impact of AD on QoL (37.7 vs. 1.8%). Patients with itch improvement had greater decreases in work time impaired (−29.3 vs. −5.6%). More patients with versus without sleep improvement reported no effect of AD on QoL (25.5 vs. 1.1%); patients with better sleep experienced larger reductions in work time spent impaired (−33.3 vs. −6.1%). Conclusions: Patients with AD who experienced itch and sleep improvement had significantly better QoL and productivity.