A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities. Issue 13 (1st July 2022)

• Record Type: Journal Article
• Authors: Feng, Jie; Zhao, Danyang; Xu, Qiannan; Liu, Xiangzhong; Zhou, Mi; Ye, Xiansheng; Lin, Ting; Wang, Guanghui; Sun, Cuiling; Ding, Rong; Tian, Wenjing; Chen, Haifeng
• Is Part Of: Natural product research. Volume 36:Issue 13(2022)
• Page Start: 3309
• Page End: 3316
• Publication Date: 2022-07-01
• Subjects: Trollius chinensis Bunge -- phenolic glycoside -- anti-inflammatory -- antibacterial; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2020.1855166
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A undescribed phenolic glycoside, trochinenol A (1 ), was isolated from the flowers of Trollius chinensis Bunge and the structure was identified by spectroscopic methods. Its anti-inflammatory and antibacterial effects were investigated by broth microdilution and NF-κB reporter gene assays. Consequently, compound 1 exhibited an appreciable effect against Staphylococcus aureus with the MIC value of 6.25 µg/mL. Besides, it showed moderate effect against TNFα-induced activation of NF-κB pathway. Graphical Abstract: UF0001