A convenient and versatile SNAr-decarboxylation protocol for the construction of C(sp2)–C(sp3) bonds. Issue 53 (14th June 2022)

• Record Type: Journal Article
• Authors: Burtea, Alexander; DeForest, Jacob; Baldwin, Neil; Leverett, Carolyn; Gallego, Gary M.
• Is Part Of: Chemical communications. Volume 58:Issue 53(2022)
• Page Start: 7435
• Page End: 7438
• Publication Date: 2022-06-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc01551j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A versatile and operationally simple one-pot procedure for the construction of C(sp 2 )-C(sp 3 ) bonds via a nucleophilic aromatic substitution-decarboxylation sequence is described. Abstract : Increasing saturation (Fsp 3 ) remains a central strategy in the optimization of properties of molecules during drug discovery. Here, we describe a versatile and operationally simple one-pot procedure for accomplishing this goal via a nucleophilic aromatic substitution-decarboxylation sequence to construct C(sp 2 )–C(sp 3 ) bonds. The method is tolerant of a variety of biologically privileged moieties and has been demonstrated in a library format.