Rhodium(iii)-catalyzed regioselective C(sp2)–H activation of indoles at the C4-position with iodonium ylides. Issue 25 (13th June 2022)

• Record Type: Journal Article
• Authors: Wu, Fuhai; Xiao, Lin; Xie, Hui; Chen, Shao-Yong; Song, Jia-Lin; Zheng, Yi-Chuan; Liu, Yan-Zhi; Zhang, Shang-Shi
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 25(2022)
• Page Start: 5055
• Page End: 5059
• Publication Date: 2022-06-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00722c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Herein, we report a Rh(iii )-catalyzed C4-selective activation of indoles by using iodonium ylides as carbene precursors. Abstract : Herein, we report a Rh(iii )-catalyzed C4-selective activation of indoles by using iodonium ylides as carbene precursors. This protocol proceeded under redox neutral reaction conditions and provided important coupling products with good tolerance of functional groups and high yields. In addition, one-pot synthesis and scale-up and mechanistic studies were also conducted.